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Clemson vs. Louisville NCAA Football Odds, Plays & Outlook | November 6, 2021

The Louisville Cardinals (4-4, 0-0 ACC) are 3.5-point losers in an ACC matchup at home with the Clemson Tigers (5-3, 0-0 ACC) on Saturday, Nov. 6, 2021 at Cardinal Stadium . The game’s over / under is set to 45.5.

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Odds for Clemson vs. Louisville

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