Friday, December 9

College football odds, picks, predictions for Week 1, 2022: Proven simulation backing Florida, Louisville


No. 9 Oklahoma is going to be a new-look team in 2022 after replacing former head coach Lincoln Riley and starting quarterback Caleb Williams. Sooners head coach Brent Venables will make his debut on Saturday afternoon when Oklahoma hosts UTEP during part of the Week 1 college football schedule. The Sooners opened as 37-point favorites, but they are now -30 in the latest Week 1 college football odds at Caesars Sportsbook. Should you be backing Venables and Oklahoma with your Week 1 college football bets?

Meanwhile, Riley and Williams will begin their respective USC tenures as 33-point favorites against Rice in the Week 1 college football lines. The Trojans are coming off a 4-8 season, which was their worst record since 1991. Before locking in any Week 1 college football picks for those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 1 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 1

One of the college picks the model is high on in Week 1: Florida (+3) covers at home against No. 7 Utah at 7 p.m. ET. Few new head coaches have generated the kind of buzz that new Gators head coach Billy Napier has in his new location. Many programs were looking to bring him in two seasons ago, but he made the decision to wait for his preferred situation in Gainesville. 

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Napier finished 2-2 in season-openers as the head coach of Louisiana, while Utes head coach Kyle Whittingham is 2-1 since 2010 in season-opening matchups against Power Five opponents. The Gators return this season with Anthony Richardson at quarterback, who Napier has been complementary of in camp ahead of the season. Additionally, Napier’s former running back at Louisiana, Montrell Johnson, gives him a known commodity in the Gators’ rushing attack.

Johnson finished with 838 yards and 12 touchdowns as a freshman, and the model thinks that he’ll finish with a workmanlike performance with over 60 rushing yards. Things are set up for a battle between the two sides, but the model confidently backs Florida as an underdog nearly 60% of the time in The Swamp on Saturday.

Another prediction: Another prediction: Louisville (-4.5) covers on the road against Syracuse at 8 p.m. ET. The Cardinals dominated this matchup last season, picking up a 41-3 win in November. They could be an underrated team coming into the 2022 season after three of their six losses came by just one score in 2021. Quarterback Malik Cunningham is back after leading the ACC in rushing touchdowns (20), becoming the second quarterback in school history to rush for more than 1,000 yards.

He put on a show against the Orange last season, accounting for five total touchdowns in the first half of the lopsided win. Syracuse has now been outscored 71-3 in its last two meetings with Louisville and is now just 29-43 in six seasons under head coach Dino Babers. The Orange had the worst passing offense in the conference last year, which is one reason why the model has Louisville covering the spread in well over 60% of simulations. See which other teams the model likes here.

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How to make college football picks for Week 1

The model has also made the call on who wins and covers in every other FBS matchup in Week 1, and it’s calling for a big favorite to go down hard in a shocking upset. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which heavy favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,600 in profit over the past six-plus seasons, and find out.

College football odds for Week 1 (via Caesars)

See full Week 1 college football picks, odds, predictions here

Friday, Sept. 2

Illinois at Indiana (-1.5, 46)

Featured Game | Indiana Hoosiers vs. Illinois Fighting Illini

TCU at Colorado (+13.5, 58.5)

Featured Game | Colorado Buffaloes vs. TCU Horned Frogs

Saturday, Sept. 3

Colorado State at Michigan (-27.5, 58.5)

Featured Game | Michigan Wolverines vs. Colorado State Rams

Cincinnati at Arkansas (-6, 51.5)

Featured Game | Arkansas Razorbacks vs. Cincinnati Bearcats

Oregon at Georgia (-17.5, 52)

Featured Game | Georgia Bulldogs vs. Oregon Ducks

UTEP at Oklahoma (-31.5, 57)

Rice at USC (-33.5, 61.5)

Utah at Florida (+3, 51)

Featured Game | Florida Gators vs. Utah Utes

Utah State at Alabama (-41.5, 62.5)

Notre Dame at Ohio State (-17.5, 58.5)

Sunday, Sept. 4

Florida State at LSU (-3, 51.5)

Featured Game | LSU Tigers vs. Florida State Seminoles

Monday, Sept. 5

Clemson at Georgia Tech (+21.5, 49)

Featured Game | Georgia Tech Yellow Jackets vs. Clemson Tigers



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