Thursday, June 17

Combining doses of different vaccines against Covid-19 increases adverse reactions

A woman receives the coronavirus vaccine in Los Angeles.

A woman receives the coronavirus vaccine in Los Angeles.

Preliminary findings from a study published in the journal ‘The Lancet’ point out that alternating doses of different vaccines against covid-19 causes mild and moderate reactions more frequent than if the standard vaccination schedules are followed, with two injections of the same preparation.

A team led by experts from the British Oxford University launched an investigation at the beginning of this year to investigate the effects of combining two doses of preparations manufactured by different pharmaceutical companies and saw that this increased the so-called reactogenicity.

This term refers to the common adverse reactions expected from a vaccine, such as a rexcessive immune response, fever, arm pain at the injection site …

The experts found that when a four-week interval was left between doses, they applied the “mix” schedules (Pfizer-BionNTech, followed by Oxford-AstraZeneca and Oxford-AstraZeneca, followed by Pfizer-BioNTech) generated more mild or moderate reactions after the second dose that if the standard procedure of not combining vaccines from different manufacturers was followed.

They also reported that any adverse effect derived from the mixture it was short-lived and they clarified that no other safety-related concerns were detected.

“Although this is a secondary part of what we are trying to explore through these studies, it is important that we inform people about these data, especially since several countries are considering using these mixed dose schedules,” he says. Matthew Snape, associate professor of pediatrics and vaccines at the University of Oxford, and lead investigator of the aforementioned trial.

The study findings suggest that “mixed dose schedules they could result in an increase in absences from work the day after immunization, and this is important to consider when planning immunization of healthcare workers, “Snape observes.

“Importantly, there are no safety-related concerns,” said the expert, who noted that the study does not determine whether the immune response “will be affected.”

Snape also says that the investigative team is confident in reporting that data. “in the next few months”.

“In the meantime, we have adapted the study to assess whether early and regular use of paracetamol reduces the frequency of these reactions “, reveals.

Experts also note that data collected from your tests were drawn from participants over 50 years of age, which is why they mention that there is a possibility that such reactions may be more prevalent in younger age groups.

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