Sunday, December 5

Covid: How metabolism influences recovery, according to a recent study

Metabolic disorders are the origin of various chronic diseases such as diabetes, obesity, hypertension and fatty liver. Conditions that can aggravate the symptoms of Covid-19.

Photo: Anna Shvets / Pexels

The Covid pandemic continues to give a lot to talk about. Fortunately, science continues to work by leaps and bounds to better understand its complex mechanisms. Such is the case with a new study spearheaded by the Fred Hutchinson Cancer Research Center, published in Natural Biotech. In which scientists sought to understand how it influences the metabolic process and its possible alterations in the recovery by Covid. It was a fairly large sample, in which the study analyzed 1,387 metabolomic proteins and 1,050 chemicals from the participants’ blood. The researchers discovered that aspects such as metabolic disorders, plasma cells and immune can predict the survival of the patient.

What did the study consist of? 364 plasma samples were taken from patients during the first month after being diagnosed with SARS-CoV-2 disease, these samples were analyzed for detect individual SARS-CoV-2 blood and lymphocytes. To be more precise, the study looked at 1,387 metabolomic proteins and 1,050 chemicals in the blood.

A group of experts in different branches of medical science were given the task of looking for alternatives to find the cause and probabilities of the victims of this virus. As a result they relied on the metabolic alteration to indicate the same. According to statements by study co-author Jihoon Lee, who is a graduate student at the Fred Hutchinson Cancer Research Center: “We know that there are a variety of immune responses to COVID-19, and the biological processes underlying those responses are not known. they understand well ”. And that is why we analyzed thousands of biological markers linked to the metabolic pathways that underlie the immune system and we found some clues about what immuno-metabolic changes can be fundamental in a serious disease.

For further context: according to experts, individuals with Covid-19 have a variety of immune responses, which can result in a silent SARS-CoV-2 infection or death. Scientists discovered Fundamental biochemical alterations that influence how lymphocytes respond to disease after analyzing blood samples from nearly 200 Covid-19 participants. These alterations are related to the intensity of the disease and can be used to predict patient survival.

In accordance with another of the study authors, Dr. Yapeng Su, Research Scientist at the Institute for Systems Biology: “We have found metabolic reprogramming that is highly specific for individual immune cell classes and even cell subtypes, and complex metabolic reprogramming of the immune system is associated with the global plasma metabolome and they are predictive of the severity of the disease and even the death of the patient ”.

In simpler words: the researchers observed that Increased severity of Covid-19 is linked to chemical abnormalities in human plasma, which also indicates a relationship with various metabolic disorders. Furthermore, the scientists found that each major innate immune subtype has several metabolic signatures, which they discovered using single-cell genomics.

This work provides important information for develop more effective treatments against Covid-19said Dr. Jim Heath, who is president and professor at ISB and another of the study’s co-authors. Many of the data sets that are collected from these patients tend to measure very different aspects of the disease and are analyzed in isolation.

However What is a metabolic disorder? A metabolic disorder occurs when there are abnormal chemical reactions in the body that disrupt this process. When this happens, you may have too many or too few substances that your body needs to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affect the part of the cells that produce energy and in particular are actively associated with an increased risk of severe Covid.

The truth is that metabolic alterations, they are the origin of a long list of chronic diseases. They occur when some important organs such as the liver or pancreas do not work properly. Some of the diseases most related to metabolism are diseases such as type 2 diabetes mellitus, prediabetes, metabolic syndrome, fatty liver, dyslipidemia, arterial hypertension, they are the main pathologies that are directly related to overweight and obesity. Also it is no secret to say that are directly related to impairments in the health of the immune system.

According to experts, one of the biggest risks that can aggravate the symptoms and the development of the disease are obese patients and that present a body mass index associated with metabolic diseases. That is why lifestyle and diet are determining aspects in the severity of Covid-19. For obvious reasons they are also the best tools for prevent and avoid complications related to the virus. In addition, it is well known that people who do not suffer from any metabolic disease have a much better prognosis if they become infected.

This is a very relevant study, which had the valuable collaboration of an outstanding group of researchers belonging to the Fred Hutchinson Cancer Research Center of Stanford University, the University of Washington and the Howard Hughes Medical Institute. Who have verified that metabolism, immune system, and cell surface receptors, could influence the susceptibility to infections, the appearance of the disease and its consequences. Fortunately, these discoveries will lead to the development of innovative, efficient and disease treatment methods that regulate virus reproduction and reduce inflammatory damage.

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